Sluiskil is a town in the Dutch province of Zeeland. It is a part of the municipality of Terneuzen, and lies about 27 km southeast of Vlissingen.
In 2001, the town of Sluiskil had 2366 inhabitants. The built-up area of the town was 0.77 km2, and contained 1080 residences. The statistical area "Sluiskil", which also can include the surrounding countryside, has a population of around 2410.